Aetiology of ulcerative colitis.

Aetiology and pathogenesis of ulcerative colitis and Crohn's disease.

Ulcerative colitis and Crohn's disease continue to baffle us with regard to their aetiology and pathogenesis. Indeed, our understanding has increased little since the early days of ulcerative colitis when the major debate concerned the role of the intestinal flora and the host's response to it. It seems well established that the familial incidence is about 10-15% and recent studies from Sweden,...

Ulcerative colitis: definition, historical background, aetiology, diagnosis, naturel history and local complications.

Diversion colitis: a trigger for ulcerative colitis in the in-stream colon?

The aetiology of ulcerative colitis is unknown. Two patients without pre-existing inflammatory bowel disease in whom end colostomy for faecal incontinence was complicated by diversion colitis in the defunctioned rectosigmoid colon, are described. In both instances, colitis with the clinical, colonoscopic, and microscopic features of ulcerative colitis developed about a year later in the previou...

Eczema of the Colon: A New Conception of Ulcerative Colitis

The aetiology of chronic non-specific ulcerative colitis remains obscure. All attempts to discover the cause of the disease by direct pathological experiment and research have failed. Therefore it seems reasonable to broaden the inquiry and to seek for similarities between this and other disease processes.

Leucine aminopeptidase with special reference to ulcerative colitis.

It has been suggested that ulcerative colitis might be associated with excessive production of histamine released locally from mast cells. These cells also contain a proteolytic enzyme, leucine aminopeptidase, which might also be released at the same time if this hypothesis were correct. The studies reported do not invalidate this concept of aetiology in ulcerative colitis but provide no positi...

RECENT ADVANCES Inflammatory bowel disease

The epidemiology, aetiology, clinical features, diagnosis, and treatment of Crohn’s disease and ulcerative colitis in children are reviewed, and areas for further research identified. (Arch Dis Child 2001;85:435–437)